Camptothecin
(S)-(+)-Camptothecin (CPT) is a cytotoxic quinoline alkaloid originated from camtotheca acuminata or Nothapodytes pittosporoides(Mappia).Camptothecin was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.
| Product | (S)-(+)-Camptothecin |
| CAS# | 7689-03-4 |
| Molecular Formula | C20H16N2O4 |
| Molecular Weight | 348.43 |
| Spec | 95%,98%,99%(HPLC) |
| Single impurity | less than 0.5% generally, or <0.1% as required |
Maoyuan Series:
1. Camptothecin with purity 98% by HPLC,in house standard.
2. Camptothecin with purity 99% by HPLC,in house standard.
Maoyuan Advantage & Support
1.Leading natural plant ingredients supplier in China with 16 years’ experience.
2.13000 square meters production area and more than yield of 300kg camptothecin per month.
3.ISO9001&ISO14001 certified and steady supply
4.Professional R&D team and strong R&D strength.
Packing & Storage
Packing with IATA required carton with 10kg/carton, or as customer required.
Stored in a cool, dry and dark place, shelf life 24 months.
Function:
Camptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I). (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Application:
1. Camptothecin is the natural starting material of Irinotecan HCl.
2. Camptothecin is the natural starting compound of 10-Hydroxycamptothecin.
3. Camptothecin is the natural starting ingredient of 7-Ethyl-10-Hydroxycamptothecin(SN-38).
4. Camptothecin is the natural starting ingredient of Topotecan HCl
5. This compound camptothecin is a featured product for Apoptosis research.
Natural origins of camptothecin
1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.
2. Nothapodytes pittosporoides(Mappia), a tree wild spread in Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.
